Danny Blind was dismissed following the 2-0 defeat to Bulgaria on Saturday which left the Dutch with an uphill battle to qualify for the World Cup in Russian Federation in 2018.
It's not over for them though, as they sit three points back of a second place spot with five matches to go, and three of those five at home.
The Netherlands have seven points after five games and trail leaders France by six points.
Blind took over from Guus Hiddink in July 2015 but was unable to save the Netherlands' UEFA EURO 2016 qualifying bid.
Daley Blind offered a message of support to his father Danny after he was sacked as head coach of the Netherlands. Now it's looking like they won't be at the 2018 World Cup either. I think the game against Bulgaria was decisive.
The Dutch now lie in fourth place in Group A of the World Cup qualifiers and look unlikely to qualify for Russian Federation 2018, despite reaching the semi-finals in 2014, and were runners-up in 2010.
Olivier Giroud's 22nd global goal gave Didier Deschamps' team the lead, but the host leveled six minutes later when Aurelien Joachim converted a penalty to become the first Luxembourg player to score against France in 39 years.
But De Ligt's dream debut quickly became a nightmare, making two fatal errors in the first 20 minutes before suffering the indignity of being substituted at half time to save further humiliation.
Holland are now facing the prospect of staying a home for two tournaments on the trot after the failed the qualify for Euro 2016 following a third-place finish at the World Cup in Brazil.
The Oranje's display left a sour taste for Holland captain Arjen Robben.
Antoine Griezmann restored the lead, also from the penalty spot, before halftime.
The Greeks, who moved above Bosnia-Herzegovina into second with their point, finished the match with nine men after Giorgos Tzavelas was also sent off in injury-time.
Arsenal star Giroud scored his second of the evening after 77 minutes after being set up by Benjamin Mendy.