But just how did the England players perform at Wembley?
Defoe played and scored twice in last June's event, playing alongside the likes of Jack Whitehall and that one off The Only Way is Essex who's married to Michelle Keegan.
Goalkeeper Joe Hart will captain the side on his 70 appearance in the absence of Wayne Rooney, Cahill and Jordan Henderson.
Southgate won't get many plaudits for his team's stodgy performance and the England manager would be foolish not to realise there is still a lot of improvements needed before the World Cup.
In order to inject some pace into the home side, Southgate introduced Jamie Vardy for Defoe and Marcus Rashford for Raheem Sterling on 60 minutes.
Former England boss Glenn Hoddle was part of the commentary team for the encounter and handed Defoe the man-of-the-match award. Lithuania drew with Slovenia and Scotland in their first two games. As for the current qualification for the upcoming mundial in 2018, Gareth Southgate's wards have so far been marked by an ambiguous result, although they still remain without defeat. Fiodor Cernych leads Lithuania and the group in scoring with three goals.
Southgate is seemingly selecting Defoe ahead of Vardy because he expects Lithuania to sit deep and deny England's forwards space to run into. Live streaming is available on Fox Sports Go, which you can access with your cable or satellite, either online or through their app. England should win by a similar score again.
The national team of Lithuania, in its new history, since 1990, has never passed the qualifying stages to the final stage of the world championships.
England now top Group F, having won three and drawn one of their four qualifying matches so far as they bid to reach Russian Federation 2018 under Gareth Southgate, Hodgson's successor. The country who finishes second advances to the second round playoff.