Neil Taylor's nasty collision with the Killybegs man earned him a deserved red card after 70 minutes and has been universally slated since for such a unsafe challenge.
Bale will be influential in the outcome of Saturday's (AEDT) blockbuster Group D clash in Dublin and Keane is braced for the Real Madrid forward's impact at Aviva Stadium.
This well-drilled Ireland team have what it takes to get a win against Chris Coleman's side and we shouldn't be anxious about the opposition.
He said: "Seamus has been a terrific captain for his country and on behalf of the FAI Board and everyone in the association, I want to send Seamus our very best wishes".
Mr O'Toole is well known in Irish sporting circles as a former Olympic swimmer.
"Your boys weren't coming off with halos on their heads", Coleman said.
"It's not usual to find that level of ferocity in tackles in the handsome game these days, so good luck to Seamus in his recovery".
Meanwhile, Welsh manager Chris Coleman defended Taylor against any backlash over the tackle saying the player did not mean to cause such extensive damage.
"First and foremost, the most important thing is Seamus Coleman", he said.
"We need these players on the pitch consistently and we're in pretty good condition".
"Neil Taylor is not really that type of player, but it's a tough one for Seamus. I have not seen it again".
The 27-year-old needs a hat-trick to move past Ian Rush's 28 global goal as Wales' all-time leading goalscorer.
However, injury concerns appear to disrupt nearly every Ireland preparation and yet again the James McCarthy saga continued in the build-up, right up to the warm-up before the game as the Everton man, who was named in the starting XI, was unable to start.
McCarthy has been released from the Republic squad for Tuesday's friendly with Iceland along with John O'Shea, Glenn Whelan and Jonathan Walters.
That rules him out of the home game against Austria on June 11 and the double-header away to Georgia and at home to Serbia in September.
And even though he is the last man between the danger posed by Gareth Bale and the Irish goal, the West Ham keeper is not having sleepless nights about what's to come.