Now Mourinho's men are out to capitalise on last Thursday's 1-1 draw in Russian Federation and book a place in the quarter-finals of a European competition the Reds are aiming to win for the first time.
United also suffered two injuries, losing Paul Pogba early on with what seemed to be a hamstring pull, and Daley Blind in the second half after a knock to the face.
It all adds up to a nightmarish situation, luckily for United they are playing arguably the worst side in the Premier League and they will soon have an worldwide break coming up for some rest and recovery.
"We should be the last team to play at the weekend".
"But in Rostov when I was speaking with the (Uefa) delegate about the conditions of the stadium, he was telling me, 'If a player gets injured, no problem, because they have insurance'".
Leaders Chelsea have not been involved in European action this season and the four other teams above United in the table - Manchester City, Arsenal, Tottenham and Liverpool - have all been eliminated and have played fewer matches this season. I don't ask for me, I ask for everyone.
The Portuguese manager added: "So I am really, really anxious with the previous generations that things are going in such a direction that envy is everywhere". In Portugal, every team that plays in Europe they play on the next Monday. Boro will also be fighting for their right to stay in the Premier League, with the club mired in the relegation places, second from bottom and three points short of safety. He works you so that when you are on the pitch, you give 200 percent, and this is what I needed at my age. "But I think that [the Premier League] is good enough to have more teams in the Champions League and the Europa League". He was so upset by Mourinho's outrage at the fixture list because not only did he have to suffer worse as a player, but he just shut up and did it, and came out at the other end with three trophies.
"This is a very hard draw", he said.
The Riverside Stadium showdown kicks off at 12:00 (GMT) on Sunday, with TV coverage in the United Kingdom getting underway at 11:00 (GMT) on BT Sport 1.
90'+4 SAVE! Romero makes a BRILLIANT save with the very last touch of the game!
"In Portugal, every team in Europe plays on the next Monday".
"Man. Utd. sold players that I would never sell, bought players that I would never buy". 'He gets millions, let him run. "I think in the fourth year he deserved to be sacked".