Scotland captain Greig Laidlaw will play no further part in the Six Nations after being ruled out with ligament damage.
The scrum-half suffered an ankle injury in Sunday's defeat to France and will be sidelined for the remaining three games.
He left the Stade de France on crutches with his right foot in a protective boot.
Scottish Rugby confirmed the 58-time capped player sustained ligament damage against the French.
But Scots head coach Vern Cotter has now been given the bad news that Laidlaw will miss the remainder of the tournament.
An ankle injury has ended Greig Laidlaw's Six Nations campaign with Scotland prematurely.
"Greig's a massive part of the squad and he's a great leader", said Ford.
"His captaincy over the past 18 months has really come through to the fore and he shows when he plays that he is a big part of what we're about".
"But we've got a leadership group together that's been there helping Greig out. It's about calming the other lads down and letting the decision-makers think clearly".
It leaves Glasgow co-captain Jonny Gray as the most likely candidate to skipper Cotter's men against the Welsh.
As well as the dilemma over the captaincy, Cotter also faces a hard choice replacing his talismanic scrum-half.
This week's edition of The Oval Office, we speak with Niall Ronan, David Arnott and talk all things Six Nations.
It is a significant if not unexpected blow for Scotland, following an encouraging start to the championship that included a win against Ireland, but Ford insists they can cope.